C. elegans EIF-3.K Promotes Programmed Cell Death through CED-3 Caspase
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منابع مشابه
C. elegans EIF-3.K Promotes Programmed Cell Death through CED-3 Caspase
Programmed cell death (apoptosis) is essential for the development and homeostasis of metazoans. The central step in the execution of programmed cell death is the activation of caspases. In C. elegans, the core cell death regulators EGL-1(a BH3 domain-containing protein), CED-9 (Bcl-2), and CED-4 (Apaf-1) act in an inhibitory cascade to activate the CED-3 caspase. Here we have identified an add...
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G. L. MacLean, Cimbebasia 2, 163 (1974); D. Robinson, Emu 90, 40 (1990); and R. E. Major, Emu 91, 236 (1991). 5. A. F. Skutch, Ibis 91, 430 (1949). 6. T. H. Clutton-Brock, The Evolution of Parental Care (Princeton Univ. Press, Princeton, NJ, 1991). 7. I. Rowley and E. Russell, in Bird Population Studies: Relevance to Conservation and Management, C. M. Perrins, J.-D. Lebreton, G. J. M. Hirons, E...
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The Caenorhabditis elegans Bcl-2-like protein CED-9 prevents programmed cell death by antagonizing the Apaf-1-like cell-death activator CED-4. Endogenous CED-9 and CED-4 proteins localized to mitochondria in wild-type embryos, in which most cells survive. By contrast, in embryos in which cells had been induced to die, CED-4 assumed a perinuclear localization. CED-4 translocation induced by the ...
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Programmed cell death (PCD) in mammals has been implicated in several disease states including cancer, autoimmune disease, and neurodegenerative disease. In Caenorhabditis elegans, PCD is a normal component of development. We find that Salmonella typhimurium colonization of the C. elegans intestine leads to an increased level of cell death in the worm gonad. S. typhimurium-mediated germ-line ce...
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Apoptosis is a natural process during animal development for the programmed removal of superfluous cells. During apoptosis general protein synthesis is reduced, but the synthesis of cell death proteins is enhanced. Selective translation has been attributed to modification of the protein synthesis machinery to disrupt cap-dependent mRNA translation and induce a cap-independent mechanism. We have...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0036584